Pharmacokinetic considerations as to when to use dried blood spot sampling
نویسندگان
چکیده
منابع مشابه
Dried blood spot sampling: practical considerations and recommendation for use with preclinical studies.
At present it is necessary to use animals to generate toxicokinetic data as part of preclinical safety studies. However, ethical standards require animal use to be carefully monitored and the principles of the 3Rs: replacement, reduction and refinement, to be considered and applied. Use of dried blood spot (DBS) samples, typically 10 to 20 µl, rather than the larger blood volumes required to ob...
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Dried blood spot (DBS) sampling for the purpose of therapeutic drug monitoring can be an attractive alternative for conventional blood sampling, especially in children. This study aimed to compare all costs involved in conventional sampling versus DBS home sampling in two pediatric populations: renal transplant patients and hemato-oncology patients. Total costs were computed from a societal per...
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ژورنال
عنوان ژورنال: Bioanalysis
سال: 2010
ISSN: 1757-6180,1757-6199
DOI: 10.4155/bio.10.159